There are a few Nintendo DS emulators that run some DS games, but never New Super Mario Bros... until now. We got our hands on one of the best Nintendo DS (and Game Boy) emulators: No$gba Gameboy Advance / Nintendo DS Emulator. This emulator will run both Nintendo DS and Gameboy games and every game that we've tried with No$gba has worked - this Nintendo DS emulator is almost perfect! The only thing that's not perfect is the sound, which is 99% there. No$gba works just like the real DS where you need to interact with the bottom screen, in this case you can use your mouse to select stuff.  There is currently no support for WFC, but hopefully future releases will support it. Also note that you'll need to unzip any roms you have to use with No$gba as it doesn't support ZIP files (only .nds).

We dumped our own ROMs to try with this emulator, but if you're unable to dump your own roms, you could try out some Public Domain Nintendo DS roms here. The last release of No$gba is free and you can download it here, but if you'd like the newest version you'll need to donate $2.50 via PayPal and then download the latest and greatest. Support the creator of this wonderful emulator by giving up $2.50 - it's totally worth it as the newest version (v2.6a) works much better than the free (v2.6).  

We used a Intel dual core, 2.66GHz to run this and it was flawless. Here are a few screenshots of games we tried with No$gba:

New Super Mario Bros - This game ran great! You can see the emulator in action thanks to Volvagia224 here.

Super Mario 64

MarioKart DS

Mario & Luigi: Partners in Time

Mario Hoops 3 on 3

Mario vs. Donkey Kong 2: March of the Minis

Mario Party DS

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Mario & Sonic at the Olympic Games | Beijing 2008

Mario Slam Basketball & Dragon Quest DS Super Mario